Suggested Use: 2 capsules daily, in divided doses, with meals
EndoLOX promotes cardiovascular health with key Mediterranean diet ingredients, including pomegranate, olive fruit, and resveratrol, the critical component of red wine. The polyphenols found in these extracts support healthy vascular gene expression, endothelial function, arterial wall integrity, and blood flow. In a randomized, double-blind, placebo-controlled trial involving 93 subjects, quercetin supplementation maintained healthy lipoprotein redox status. EndoLOX provides the next-generation quercetin, isoquercetin, with 2-6 times greater bioavailability than quercetin for maximum support. In a randomized, controlled trial involving 18 individuals, supplementation with polyphenol-rich olive oil maintained healthy lipoprotein integrity, partially due to the powerful antioxidant activity of the compound hydroxytyrosol. Oligonol® is a polyphenol complex from lychee fruit and green tea produced by converting the long-chain polyphenol polymers into more bioavailable shorter chain monomers and oligomers; these compounds help to maintain cytokine balance and promote antioxidant defenses to support lipoprotein status and cellular health. Berberine supports healthy glycemic response and helps maintain healthy LOX-1 gene expression, important mechanisms for maintaining endothelial integrity and lipoprotein metabolism. N-acetyl-l-cysteine (NAC) is included in this formula to support healthy immune mediator activity in the artery wall to support healthy lipoprotein function.
What Is It?
EndoLOX is designed to support cardiovascular health with key Mediterranean diet
ingredients, including pomegranate, olive fruit and resveratrol, a critical component
of red wine. The blend supports powerful antioxidant defenses to promote vascular
tissue, lipoprotein metabolism, endothelial function and cellular health.*
Uses For EndoLOX
EndoLOX offers support for healthy vascular gene
expression, endothelial function, arterial wall integrity and blood flow. The formula
is designed to enhance LOX-1 receptor function to support healthy lipoprotein
metabolism. LOX-1 is a macrophage receptor protein involved with binding and
breaking down lipoproteins. Research suggests berberine, ellagic acid, and
resveratrol moderate LOX-1 receptor function, in part by supporting antioxidant
defenses, cytokine production, and healthy iNOS activity. Additionally, the formula
offers a number of unique extracts designed to provide powerful antioxidant
support to promote healthy lipoprotein status and cellular membrane stabilization.
First, enhanced absorption isoquercetin offers 2-6 times higher bioavailabity
compared to quercetin. In a randomized double-blind, placebo-controlled trial
involving 93 subjects, supplementation with 150 mg quercetin provided antioxidant
support to maintain healthy lipoprotein status and promoted healthy blood flow.
Hydroxytyrosol from olive fruit is included for its ability to promote healthy
cytokine balance and moderate the expression of vascular adhesion molecules.
In a randomized controlled trial involving 18 individuals supplemented with olive
oil, olive oil with a high polyphenol content offered enhanced antioxidant support
for healthy lipoprotein metabolism. Oligonol
is an extract from lychee fruit and
green tea produced by converting the long-chain polyphenol polymers into more
bioavailable shorter chain monomers and oligomers. Increasing the bioavailability
of these polymers offers enhanced support for cytokine balance and antioxidant
defenses to support lipoprotein status and cellular health. Lastly, N-acetyl-l-
cysteine (NAC) is included to help maintain a healthy balance of immune mediators
in the artery wall to support healthy lipoprotein function.*
What Is The Source?
Berberine HCl is derived from
bark and Sargent’s
barberry(Berberis sargentiana). Isoquercetin is derived from Fava d’anta tree(Dimorphandra mollis) pods and Cat’s claw (Uncaria tomentosa) leaves. N-acetyl-
l-cysteine and resVida
resveratrol are synthetic. Pomegranate extract is derived
Punica granatum l.
fruit and standardized to contain 70% ellagic acid.
olive extract is derived from
Olea europaea l.
fruit and standardized
to contain a minimum of 7% hydroxytyrosol. Oligonol
is derived from lychee
fruit extract and green tea (
) leaf extract and
standardized to contain 10% monomeric phenols. Ascorbyl palmitate is derived
from corn dextrose fermentation and palm oil.
Pure Encapsulations recommends 2 capsules daily, in divided doses, with meals.
Are There Any Potential Side Effects Or Precautions?
Not to be taken by pregnant or lactating women. Berberine has had reports of
headache, nausea, vomiting, abdominal bloating, hypotension and slowed heart
rate in the literature. It is recommended to use resveratrol cautiously in patients
with hormonal disorders and those using estrogen therapy, as resveratrol may
act as either an estrogen agonist or estrogen antagonist. There have been
rare reports of headache or tingling in the extremities resulting from quercetin
supplementation. There have been cases of allergic reaction to lychee fruit.
Individuals with allergy to birch pollen, latex,
pollen and sunflower
seed should be cautious of potential cross-reactivity. In rare cases, green tea can
cause dizziness, insomnia, agitation or fatigue. Rare side effects from NAC can
include nausea, vomiting, headache, dry mouth, dizziness, or abdominal pain.
Consult your physician for more information.
Are There Any Potential Drug Interactions?
, quercetin and resveratrol have blood-thinning effects and therefore
may be contra-indicated with blood thinning medications. Individuals taking
anti-diabetes medications may require blood glucose monitoring. Berberine may
be contra-indicated with blood pressure medications. Quercetin could affect the
way that the liver breaks down medications metabolized by the cytochrome p450
system, altering the effects of these medications and possibly the dose needed
for treatment. Quercetin may be contra-indicated with calcium channel blockers,
estradiol, and immune suppressive drugs. Green tea extract may interfere with the
absorption and effectiveness of a number of other medications, including certain
heart, anti-diarrhea, cold and hay fever medications. NAC may interact with
nitroglycerin and metoclopramide. Consult your physician for more information