Suggested Use: 2 capsules, twice per day, with meals.
PureDefense w/NAC -
Natural killer cells are part of the body's innate, or first-line, immune response. They respond more quickly than the adaptive immune system comprised of B cells and T cells. Once activated, natural killer cell activity peaks in as quickly as several hours, providing rapid support and wide-range immune defense. EpiCor® is a fermentate of Saccharomyces cerevisiae containing various bioactive metabolites. These nutrient metabolites are produced in a specialized fermentation process and enhance im
In one cellular study, EpiCor® promoted
natural killer cell activation, as well as that of B cells and T
cells. In two randomized, double blind, placebo-controlled
trials, EpiCor provided statistically significant support for
upper respiratory tract health and overall immune health.
A separate open label, in-house trial indicated a strong
potential for EpiCor supplementation to enhance secretory
IgA levels after 30 days. These various actions demonstrate
the ability of EpiCor® to address both innate and adaptive
immune responses. NAC promotes endogenous glutathione
production for antioxidant protection and provides
lung defense mechanisms for healthy respiratory
function. In a randomized double blind trial involving
mostly older individuals, NAC supported comfort, nasal
function and respiratory health through the winter months.
Vitamin C, vitamin D and zinc provide nutritional immune
support, enhancing healthy immune cell proliferation,
activation and function. Vitamin D receptors have been
found on a number of immune cell types, and it is
believed to play an important role in seasonal immune
health. Vitamin C and the bioflavonoid quercetin also help
boost immune defense by supporting healthy antioxidant enzyme function.
Immune Support Advances*
By Mark Swanson, ND
Several studies this year highlight new approaches for environmental immune support. Optimal immune function often requires a multi-modality approach, typically involving a combination of nutrients and herbal ingredients. Emerging research suggests that a Saccharomyces cerevisiae fermentate and specialized probiotic strains may offer additional immune support.*
EpiCor® is a fermentate of Saccharomyces cerevisiae containing various bioactive metabolites. Research indicates that it enhances immune cell production and supports innate and adaptive immune responses. In the upper respiratory tract, EpiCor® promotes natural killer cell activation, B-cell and T-cell function, and secretory IgA.1 A recent 12 week randomized double blind, placebo-controlled trial suggests that EpiCor® may also help maintain a healthy immune response to environmental factors. In this trial, participants were given 500 mg EpiCor® daily. Results indicate statistically significant support for nasal function and comfort, as well as positive but non-significant support for ocular health. These results are generally attributed to its ability to promote healthy salivary IgA, eosinophil and lymphocyte production and function.*2
A recent review of 12 trials suggests that probiotics also offer unique support for maintaining healthy immune function in response to environmental triggers.3 Healthy microflora balance has been associated with immune response. Research on the novel probiotic Bifidobacterium longum BB536 suggests that supplementation helps maintain a normal microflora balance in sensitive individuals.4 In a two-way crossover study, twice daily administration of BB536 maintained ocular and nasal function as well as overall comfort.5 A 13 week randomized, double blind, placebo-controlled trial suggests that it also promotes healthy immune response, inflammatory balance, cytokine production and IgE function.6*
First line support is based on the ability to maintain healthy immune function and comfort during occasional environmental exposures. New research advances, including studies on Epicor® and Bifidobacterium longum BB536, offer unique approaches that can easily be combined with other complimentary supplements for the widest spectrum of support.*
Moyad MA, Robinson LE, Zawada ET, et al. Effects of a modified yeast supplement on cold/flu symptoms. Urol Nurs. 2008;28:50-55
Moyad, MA, Robinson LE, Bubak, ME, et al. Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double blind, placebo-controlled trial. Advances in Therapy. Int. Journal of Drug, Device & Diagnosis Research. 2009;26(8)795-804.
Vliagoftis H, Kouranos VD, Betsi GI, Falagas ME. Probiotics for the treatment of allergic rhinitis and asthma: systematic review of randomized controlled trials. Ann Allergy Asthma Immunol. 2008 Dec; 101(6):570-9.
Odamaki T, Xiao JZ, Iwabuchi N, et al. Fluctuation of fecal microbiota in individuals with Japanese cedar pollinosis during the pollen season and influence of probiotic intake. J Investig Allergol Clin Immunol. 2007;17(2):92-100.bacterium
Xiao JZ, Kondo S, Yanagisawa N, et al. Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergol Int. 2007 Mar;56(1):67-75.
Xiao JZ, Kondo S, Yanagisawa N, et al. Probiotics in the treatment of Japanese cedar pollinosis: a double-blind placebo-controlled trial. Clin Exp Allergy. 2006 Nov;36(11):1425-35.
For educational purposes only. Consult your physician for any health problems.
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
Suggested Use: 2 capsules, twice per day, with meals.
|vitamin C (ascorbic acid||500 mg||-|
|vitamin D3||2,000 IU||-|
|zinc (citrate)||15 mg||-|
|n-acetyl-l-cysteine (free-form)||900 mg||-|
|EpiCorŪ dried yeast fermentate complex (from Saccharomyces cerevisiae)||500 mg||-|
|elderberry extract (fruit)||400 mg||-|
|vitamin C (as ascorbyl palmitate)||40 mg||-|
Other Ingredients: -
(-) There is no %DV or the manufactuer has not provided this data.
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