MotilCalm

MotilCalm is an advanced gut signaling support formula, maintaining healthy GI contractile function, mucosal protection, normal inflammatory balance and immune function.*

Uses For MotilCalm

G.I. Motility: Proper gastrointestinal motility is essential for optimal rates of nutrient and fluid absorption, elimination of toxins and overall abdominal comfort. GI motility is regulated by over 100 million neurons embedded in the walls of the GI tract. Collectively known as the enteric nervous system, or the “gut brain,” these neurons communicate by way of numerous neurotransmitters and neurohormones to coordinate smooth muscle contraction. Clinical studies indicate that supplemental melatonin calms the intestinal tract, provides mucosal protection, maintains normal inflammatory balance and promotes immune function in the GI tract. Melatonin also supports the normal regenerative capacity of the epithelia. Ginger promotes gastric emptying and upper GI comfort and may relieve occasional nausea. Ginger also supports mucosal glutathione levels and maintains healthy mucosal cytokine and eicosanoid production. Clinical evidence has indicated the value of Boswellia serrata in maintaining slower contractile patterns of intestinal smooth muscle. AKBA, a major triterpenoid in boswellia, promotes mucosal integrity and healthy leukotriene balance in the ileum and colon. Curcumin supports healthy TNFα production and gene expression through nuclear factor kappa B activity. Quercetin supports intestinal barrier function and complements melatonin in maintaining normal neuromuscular activity in the ileum and colon by maintaining presynaptic acetylcholine retention at neuromuscular junctions of the GI tract.*

What Is The Source?

Curcumin C3 Complex® turmeric extract is derived from Curcuma longa root and standardized to contain 95% curcuminoids. Ginger extract is derived from Zingiber officinale root and standardized to contain 5% gingerols. 5-LOXIN® AKBA boswellia serrata extract is derived from gum resin and sstandardized to contain 30% 3-acetyl- 11-keto-beta-boswellic acid (AKBA). Quercetin is derived from Japanese pagoda tree (Sophora Japonica) flower buds. Melatonin is synthetic. Ascorbyl palmitate is derived from corn dextrose fermentation and palm oil. Curcumin C3 Complex® is a restereted trademark of Sabinsa Corporation. AKBA boswellia serrata extract. 5-LOXIN® is a registered trademark of PL Thomas - Laila Nutra, LLC and is used under license. International Patents Pending.

Recommendations

Pure Encapsulations recommends 3 capsules per day, in the evening, ½ to 1 hour before bedtime.

Are There Any Potential Side Effects Or Precautions?

Not to be taken by pregnant or lactating women. Rare side effects of boswellia or turmeric include GI upset, acid reflux, diarrhea or skin rash. May have sedating effects and is for bedtime use only. This product may be contraindicated in depression, seasonal affective disorder, schizophrenia, autoimmune disease, diabetes or asthma. Common reported side effects include daytime drowsiness, headache, and dizziness, but these do not seem to occur any more frequently than with placebo. It has also been associated with depression, anxiety, abdominal cramps, irritability, nausea, vomiting or hypotension. Consult your physician for more information.

Are There Any Potential Drug Interactions?

Ginger, curcumin and melatonin may be contra-indicated with blood thinning medications. Studies suggest boswellia moderates 5-lipoxygenase and therefore may interact with leukotriene inhibitors. Quercetin may react with calcium channel blockers, estradiol, and immune suppressive medications. Melatonin should not be taken inconjunction with antidepressants, beta blockers, MAO inhibitors or corticosteroids. Consult your physician for more information.