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Suggested Use: 2-3 capsules per day, in divided doses, with meals

Petadolex® - Petadolex is a natural, herbal supplement made from butterbur that has been proven to reduce the frequency and intensity of migraine attacks. Petadolex was developed in the 1970s and has been used throughout Europe for over 25 years. Petadolex is manufactured by Weber and Weber, a renown German pharmaceutical company. Petadolex was patented in the US in 2003 and has been gaining in popularity due to doctor referrals and articles in medical journals such as Headache and Neurology.

What Is It?

Butterbur is a perennial shrub with a 2,000-year history of traditional use. In the last twenty-five years, it has been trusted extensively throughout Europe by neurologists and other health professionals. It has been studied for healthy cranial vessel support.*

Uses For Petadolex®

Cranial Vessel Support: In one clinical trial with 60 participants, Petadolex showed the potential to support cranial vessel comfort and was well tolerated. After a twelve-week period, almost eighty percent of participants supplementing with Petadolex indicated a supportive effect. In part, the mechanism for this action may involve a supportive spasmolytic effect on smooth muscle in cranial blood vessels. A second study with 229 individuals indicated similar positive results. In this trial, optimal dosing of Petadolex provided significant support compared to placebo within one month. After three months, over seventy percent of individuals experienced a positive outcome.*

Maintain Healthy Histamine Release: A petasin-containing butterbur extract has been shown to maintain healthy histamine and cytokine release. In two clinical trials, butterbur maintained healthy nasal histamine release and leukotriene activity, supporting both subjective and objective parameters.*

What Is The Source?

Petadolex® is a patented form of butterbur extracted from the root and standardized to contain a minimum of 15% petasin and isopetasin. It is processed to remove pyrrolizidine alkaloids. Petadolex® is a trademark of Weber & Weber. Manufactured for Pure Encapsulations, Inc. by Weber & Weber. Product of Germany.


Pure Encapsulations recommends 2-3 capsules per day (providing 14.4-23.4 mg petasins), in divided doses, with meals.

Are There Any Potential Side Effects Or Precautions?

If pregnant or lactating, consult your physician before taking this product. There have been very rare reports of mild gastrointestinal discomfort with butterbur.

Are There Any Potential Drug Interactions?

At this time, there are no known adverse reactions when taken in conjunction with medications.

Supplement Facts:
Suggested Use: 2-3 capsules per day, in divided doses, with meals
Each Capsule contains:
petasins (from purple butterbur (petasites hybridus) extract (root))7.5 mg-
Other Ingredients: riboflavin, glycerol, gelatin capsule (gelatin, glycerin, water), sorbitol
(-) There is no %DV or the manufactuer has not provided this data.
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