Suggested Use: As a dietary supplement, take 1 capsule, 1-2 times
daily, with meals.
Choline (bitartrate) -
Key vitamin to support healthy methylation, cell function and neurotransmissioná
While long considered a non-essential vitamin,
recent evidence confirms that the body cannot
synthesize enough choline to meet daily needs. This
has prompted the National Academy of Science to
create a daily value for choline of 550 mg. Dietary
intake of choline is often below this level.1 Choline is
an important nutrient for methylation, cell
membrane structure and neurotransmission, and
lipid metabolism and transport. Choline and its
metabolites are the major source of methyl groups
in the diet. Methylation plays many roles including
neurotransmission, vitamin assimilation, DNA
synthesis and gene regulation.2 Choline is required
for the synthesis of phospholipids and acetylcholine,
a neurotransmitter involved in attention, learning
and memory.3 Certain genetic variations in MTHFD1
and PEMT, enzymes that play critical roles in
methylation and phosphatidylcholine synthesis,
respectively, have been associated with increased
dietary choline needs.4-6 Since the de novo synthesis
of phosphatidylcholine requires the estrogeninducible PEMT enzyme, women with low estrogen
levels and/or certain SNPs in the PEMT gene have
increased choline needs.7 Postmenopausal women
with lower estrogen have higher dietary cholinerequirements because of reduced PEMT function.8
Choline requirements also increase during
pregnancy.9 One clinical trial showed that women
who consumed 480 mg of choline daily during
pregnancy had offspring with faster processing
speed than those who did not.10 A randomized,
double blind, placebo-controlled trial suggests that
higher intakes of choline also promote healthy
hepatic fat metabolism.11
Suggested Use: As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.
|Choline (as choline bitartrate)||275 mg||-|
Other Ingredients: vegetarian capsule (cellulose, water), tri-magnesium citrate
(-) There is no %DV or the manufactuer has not provided this data.
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